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Protein kinase C inhibits type VI adenylyl cyclase by phosphorylating the regulatory N domain and two catalytic C1 and C2 domains

In Greer, J.P., Foerster, J., Rodgers, G.M., Paraskevas, F., Glader, B., Arber, D.A., Means Jr., R.T

Because mitochondria naturally produce free radicals during energy production, antioxidant systems like glutathione play an important role in helping maintain balance

Further experiments confirmed that acrylamide decreased mitochondrial membrane potential (MMP) and increased ROS production and Nrf2 levels, leading to GSH deactivation and GPX4 degradation and inevitably inducing oxidative stress and ferroptosis (47,104)