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For instance, chronic doxorubicin (DOX) intervention can also lead to cardiomyocyte aging, suggesting that the aging mechanism shares many irreversible stress factors with the cardiac injury pathway, such as decreased Sirtuins expression, increased p38 mitogen-activated protein kinases (p38MAPK) signaling, and decreased antioxidant enzyme levels represented by MnSOD [21, 22]

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Fazzari M, Trostchansky A, Schopfer FJ, Salvatore SR, Snchez-Calvo B, Vitturi D, Valderrama R, Barroso JB, Radi R, Freeman BA, Rubbo H (2014) Olives and olive oil are sources of electrophilic fatty acid nitroalkenes

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Notably, supplementing exogenous H 2 S donors (such as NaHS) can effectively reverse the spermatogenic defects and infertility seen in Asb1 -knockout mice