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A deeper understanding of mitochondrial metabolic reprogramming in CRC, particularly its involvement in therapeutic resistance, metastatic adaptation, and metabolic vulnerabilities [14], is essential for the development of targeted interventions and the advancement of precision oncology

And I mentioned that it's a very powerful activator of Nrf2

doi: 10.1093/nar/gkz979 147 KimBWJeongYEWongMMartinLJdamage accumulatesDNA