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*Eligible patients without diabetes but with a BMI of 30, or 27 with comorbidities, lost an average of 21% of their body weight (-48 lbs) in a 72-week clinical trial evaluating 15 mg of tirzepatide, when combined with a reduced-calorie diet and increased physical activity

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Excessive NNMT activity can lead to a reduction in NAD+ and SAM levels

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