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Superoxide radical scavenging by ascorbate is approximately 100 times more effective than that by glutathione (rate constants 3 10 5 M 1 s 1 vs 1 10 3 M 1 s 1 ) (Zhitkovich 2020)

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6 Gut microbiota dysbiosis and cytokine abnormalities 6.1 Evidence for the association between cytokines and schizophrenia Given the dysfunction of the BBB in patients with schizophrenia, changes in cytokine levels in the periphery (peripheral blood) and the center (cerebrospinal fluid, CSF) are valuable for assessing the CNS inflammatory state

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67 Rapamycin was initially approved by the FDA in 1999 as an immunosuppressant for treating posttransplantation autoimmunity, which specifically suppresses the activity of mTORC1 in mTOR signaling and eventually disrupts cell proliferation and cell cycle progression of T cells while promoting immunosuppressive Treg development from nave T cells