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In parallel, Resveratrol enhances the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, upregulating activating transcription factor 4 (ATF4) and ATF6, this suppresses endoplasmic reticulum (ER) stress markers, including CCAAT/enhancer binding protein homologous protein (CHOP), glucose-regulated protein 78 (GRP78), and X-box binding protein 1 (XBP1), while boosting the activity of antioxidant enzymes such as SOD, CAT, and GSH-Px, as well as controlling NAD phosphate (NADPH) oxidase-mediated ROS generation, reducing lipid peroxidation markers like MDA levels, and suppressing nitric oxide (NO) overproduction, thereby exerting anti-inflammatory and anti-oxidant effects (92, 95)

Caspase 3 activity was measured as arbitrary fluorescent units

doi: 10.1186/s13148-023-01487-9 279 GuoJLiMZhaoYKangS-GHuangKTongT

Hyaluronic Acid and Vitamin E: Two of the most hydrating antioxidants to help revitalize and nurture the skin to a plump and dewy glow