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38th ed

doi:10.1111/cea.12490

Where excessive glucuronidation has been observed, structural modifications have been incorporated to reduce this, such as in the design of a novel class of oxetane indole-amine 2,3-dioxygenase (IDO1) inhibitors [13] Here introduction of a hydroxyl group to improve polarity also had a positive effect on the off-target profile, but which was subject to O -glucuronidation