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Mitochondria are also involved in calcium and reactive oxygen species (ROS) homeostasis

doi: 10.1016/j.bcp.2020.113973

Frank suggested oral tranexamic acid (yep, the same stuff in that serum, but in pill form)

However, this is not a fundamental limitation of the technique and perturbations such as inharmonicity can also be incorporated to handle phenomena such as stiff strings (Smith, 2010)