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doi: 10.1128/mBio.02094-21 53 DavisD

ADH = Antidiuretic hormone (vasopressin) ARBs = Angiotensin receptor blockers BBB = Blood brain barrier BKN = Bradykinin CFS = Chronic Fatigue Syndrome COMT = Catechol-O-methyltransferase CRH = Corticotropin-releasing hormone CVOs = Circumventricular organs DAO = Diamine oxidase EDS = Ehlers Danlos syndrome FB = Fibromyalgia Glu = Glutamate GnRH = Gonadotropin releasing hormone Hcy = Homocysteine HNMT = Histamine N-methyltransferase HPA = Hypothalamus-pituitary-adrenal LC = Long COVID MCAS = Mast cell activation syndrome MTHFR = Methylenetetrahydrofolate reductase P5P = Pyridoxal-5-phosphate POTS = Postural orthostatic tachycardia syndrome PVN = Paraventricular nucleus RLS = Restless legs syndrome SAMe = S-adenosylmethionine SIBO = Small intestine bacterial overgrowth Introduction COVID-19 has unleashed a tsunami of research that has been further energized by the persistent and debilitating aftermath of Long COVID

Br J Pharmacol 116:19992004 Naseem KM (2005) The role of nitric oxide in cardiovascular diseases

6 The screening model is valuable precisely because it is sensitive, but that sensitivity is also its limitation: many agents that look promising on dermal papilla cells never translate into clinically meaningful regrowth, because a follicle in a dish is insulated from the hormonal, vascular, immune, and mechanical realities of a living scalp

Nephron 2018;138:12936.