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Nature 539 , 384389 (2016)

A healthcare professional should always be consulted before taking any dietary supplements while pregnant or nursing, especially if there are known allergies or medical issues

[181] The Blue Mountains Eye Study reported a higher prevalence of posterior subcapsular cataracts among users of high-dose thiamine and pyridoxine (vitamin B6) supplements

Those with severe deficiencies may require higher doses of vitamin B12, which can cause side effects including dizziness, headache, anxiety, nausea, and vomiting (Al Amin, 2021)

At 428.302(b)(4)(iii), we proposed that if a generic Part D rebatable drug or biosimilar that is currently in shortage experiences a severe supply chain disruption, the manufacturer may submit a severe supply chain disruption rebate reduction request