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This damages mitochondrial and other cell membranes and structures, leading to cell injury and death (3)

Effects of an amino acid solution enriched with either branched chain amino acids or ornithine-alpha-ketoglutarate on the postoperative intracellular amino acid concentration of skeletal muscle

While this strategy is inherently challengingrequiring extensive patient recruitment, substantial time investment (typically years for follow-up), significant financial resources, and multi-center collaboration to ensure sample representativenessit remains valuable for validating clinical translatability