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S1 consists of the NTD, the RBD, and subdomain 1 and 2 (SD1 and SD2)

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Targeting key NAD + -consuming enzymes, glycolytic proteins, and components of the tricarboxylic acid cycle/electron transport chain (TCA/ETC), as well as markers of mitochondrial dynamics and signaling/transcription molecules/factors, revealed a metabolic dysfunction in CD4 + , but not CD8 + T cells of APP carriers, as compared to healthy individuals (Fig

10.1021/acssynbio.0c00060

Following discovery of a sparse number of occurrences of progressive multifocal leukoencephalopathy (PML) in those taking a FAE, median duration of FAE therapy to PML symptom onset or appearance of first PML brain lesion was 31 months (range 6110), with median duration of lymphocytopenia to PML symptoms being 23 months (range 672)