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In contrast, pathways involved in metabolism, such as alanine, aspartate, and glutamate metabolism, biosynthesis of secondary metabolites, and C5-branched dibasic acid metabolism, displayed a balance of upregulated and downregulated genes

IGF-1 LR3 is a synthetic 83-amino acid analog of human Insulin-Like Growth Factor-1, modified specifically to resist neutralization by IGF binding proteins in laboratory and preclinical research settings