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If the distribution of confounding factors differs in the two arms, explicative regression analysis will be performed in which the dependent variable will be the normalisation of the serum vitamin B12 concentration, and the independent variable will be the treatment group

Methodological quality was assessed using the Newcastle-Ottawa Scale for cohort studies

Caffeine and nicotine have also been shown to modulate cortical excitability in a dose-dependent manner (110, 111)

In animal models of wound healing, it accelerates closure of full-thickness skin wounds, and in cardiac infarction models, it promotes epicardial neovascularization