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DLG5 (discs large homolog 5), which is transcriptionally regulated by progesterone [88], is expressed at a significantly low levels in tamoxifen-resistant BC cells

8-oxo-dGuo is by far the most extensively studied lesion that arises as a consequence of oxidative DNA damage Citation[144,150,153]

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[,] In animals, splenectomy attenuates concanavalin A (ConA)-induced hepatic fibrosis in mice by decreasing serum levels of TNF superfamily 14 (TNFSF14, or LIGHT), which can promote fibrosis through direct binding to TNFRSF3 (lymphotoxin receptor, LTR), but not TNFRSF14 (herpesvirus entry mediator, HVEM) on hepatic macrophages to increase JNK-mediated TGF-1 expression

Over time, large numbers of old (or senescent) cells can build up in the bodys tissues