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Journal of Pharmaceutical Sciences, 112(5), 2189-2204.

Notably, outliers detected both at PRE-START and at the time of DARA treatment failure pointed to biologically distinct, potentially genetically driven MM subgroups with divergent therapeutic responses ( Figure 5 ) confirmed consistent detection of ADO and INO but revealed divergent dynamics, highlighting the need for personalized metabolic monitoring

As vitamin B12 is not stored in the body, therefore excess amounts are often removed in urine

This includes individuals with medical conditions such as pernicious anemia, atrophic gastritis, celiac disease, or Crohns disease, all of which can interfere with B12 absorption