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Gregg, E

Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle

This retrograde signaling from mitochondria to nucleus increases expression of cytoprotective enzymes, helping cells cope with oxidative stress

Common clinic signs include: Chronic or recurring vomiting Diarrhea (often with mucus or blood) Weight loss Lethargy Poor coat quality Decreased appetite These symptoms often appear gradually and may come and go, making them easy to overlook at first

If this happens very gently internally and externally rotate the patients arm