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In decreasing order, the most frequent neoplasms in NF1 are optic nerve glioma (ONG) (15%-20%), malignant peripheral nerve sheath tumor (MPNST) (8%-13%), gastrointestinal stromal tumors (4%-25%), and pheochromocytomas (0.1%-5%).35 In addition, patients with NF1 are at 7 to 5 times greater risk than the general population of developing leukemia, brain tumors, and breast cancer

Brazil J Biol 79(1):12732 Raji P, Samrot AV, Bhavya KS, Sharan M, Priya S, Paulraj P (2019) Greener approach for leather tanning using less chrome with plant tannins and tannins mediated nanoparticles

Once the hepatotoxicity due to APAP was recognized, the mechanisms behind this were extensively investigated, especially in the mouse model, which recapitulates key mechanistic aspects of liver injury in humans such as mitochondrial dysfunction [5,6]

Different studies supported that TGF-1 suppresses gene expression of glutamate cysteine ligases (GCL), an enzyme implicated in the biosynthesis of GSH, in alveolar epithelial cells (Jardine et al., 2002)

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