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When the serum calcium level is high , it suppresses the release of PTH (via negative feedback ), helping to reduce the serum calcium level

It interferes with the absorption of the B12intrinsic factor complex in the terminal ileum

Furthermore, excessive accumulation of NADH in conjunction with reduced NAD + availability can inhibit glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity in the glycolytic pathway, leading to glucose shunting to the glycolytic branch pathway (Yan et al., 2016