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619 Overall, DNA methylation levels decrease in SLE patients, and disease activity and progression in lupus patients are negatively correlated with methylation patterns, 620,621 primarily due to the reduced expression/activity of DNMTs

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The observation that DPP1 knockout mice are resistant to NSP-driven experimental diseases supports the therapeutic strategy of DPP1 inhibition (155, 190)

285 And with the development of electrostatic spinning technology, nanofiber membranes have become an option for controlled drug release, Chen et al injected PRP into nanofiber core shells to mimic the secretion of synovial fluid and growth factors in normal tendon sheaths 189 (Figure 5c)

Although compounds such as vitamins, polyphenols, and plant-derived molecules have demonstrated promise in preliminary studies, more comprehensive clinical trials are needed to confirm their therapeutic value, determine optimal dosages, and assess long-term safety