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Normalized endothelium tends to form tighter interendothelial junctions between neighbouring cells, which involve adhesion junction molecules such as tight junctions (e.g., zona occludens (ZO)1, ZO-2 and Claudin-5) [125]

Interestingly, a functionally similar mechanism has been previously suggested for neurotrophins (BDNF, NGF, and NT3): all these factors are zinc-binding proteins and undergo Zn 2+ -induced deactivating conformational changes that in the case of BDNF, prevent it from interacting with its receptor TrkB 87,88

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Oral minocycline in the treatment of vitiligoa preliminary study