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(PubMed) Harris WS, Sands SA, Windsor SL, et al

MSCs typically reside in a hypoxic niche in vivo

69 Thirdly, during the DPN, excess saturated fatty acids (SFAs) and hyperglycemia depolarize mitochondrial membranes and generate ROS, 70 which eventually produce mitochondrial dysfunction and Schwann cells (SCs) apoptosis

The virus forces the host cell to use these specific pathways for massive de novo purine biosynthesis in order to rapidly replicate viral RNA