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This study clearly defines a dual-action mechanism of PFs: direct antioxidant defense through activation of the Nrf2 pathway, which is required for the mitigation of cell injury caused by chronic heat stress and detoxification of the liver during mycotoxin exposure, and an indirect protective effect achieved by blocking the antagonistic NF-B signaling cascade and modifying the gut flora

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Parker JO, Parker JD, Caldwell RW, Farrell B, Kaesemeyer WH