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Some prodrugs require specific enzymes or endogenous compounds for hydrolysis, such as the carboxylesterases including acetylcholinesterase, butyrylcholinesterase and arylesterase that are critically involved in the bioconversion of ester-based prodrugs into pharmacologically active forms (Liederer and Borchardt, 2006)

The prognostic value of elevated plasma TMAO for cardiovascular risk remained significant in various subgroups associated with a reduced overall risk of major cardiovascular events

Pain 16 , 10771086 (2015)

Differential Expression Level of Cytokeratin 8 in Cells of the Bovine Nucleus Pulposus Complicates the Search for Specific Intervertebral Disc Cell Markers