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Neuropsychopharmacol: Off Publ Am Coll Neuropsychopharmacol (2017) 42:2292300

Later studies confirmed that simultaneous stimulation of two independent signaling pathways the GHRH-R/cAMP/PKA pathway (activated by GHRH analogs) and the GHS-R1a/IP3/DAG pathway (activated by ghrelin, GHRP-6, or Ipamorelin) produces GH release several-fold greater than the sum of individual effects