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However, to promptly address the most pressing concern, the proposed 4-star maximum functions as an interim step, allowing hospitals and interested parties additional time to prepare for Stage 2: Stage 2: Implement a Blanket 1-Star Reduction for Hospitals in the Lowest Quartile of Safety of Care Measure Group Performance for the 2027 Overall Hospital Quality Star Ratings and Later Years ( 412.190(d)(9)(ii)) We proposed to reduce the Overall Hospital Quality Star Rating of any hospital in the lowest quartile of Safety of Care (based on at least three measure scores) by 1 star, to a minimum 1-star rating

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Acute toxicity in animal models is described as low for all three peptides individually, but coadministration data are sparse