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Least square mean percent liver fat reduction at end of treatment was 22.8% (p=0.0010) with 3 mg and 17.5% (p=0.0267) with 6 mg FXR314, compared to 6.1% in the placebo group

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F2,6BP is crucial for the activation of PFK1 (phosphofructokinase 1) in the glycolytic pathway