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Following the designated treatments, the rectal region was locally exposed to a single dose of 20 Gy X-ray irradiation, as determined in preliminary dose-selection experiments (see Supporting Information)

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138 The interaction between CST1 and GPX4 improves the stability of GPX4 protein and reduces the intracellular ROS, thus inhibiting ferroptosis

Zachara BA (2015) Selenium and selenium-dependent antioxidants in chronic kidney disease

1 Introduction Vitamin E is an essential micronutrient and a fat-soluble vitamin that acts as an antioxidant in the detoxification chain of fat-soluble to water-soluble toxic radicals