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They can also be produced via various laboratory methods, such as solid-phase peptide synthesis (SPPS)

In addition to its effects on insulin, GIP plays a crucial role in fat accumulation by promoting the activity of adipocyte-expressed lipoprotein lipase and promoting bone formation by preventing osteoclast apoptosis, as evidenced by the thinner bone trabeculae seen in mice lacking GIP receptors [20,21,22]

There was also a dose-dependent effect on BW gain, but no effect on total IGF-I levels, IGFBPs, or serum markers of bone formation and resorption