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9 In addition, combined oral contraceptives appear to limit conversion of testosterone into the more potent androgen 5--dihydrotestosterone by inhibiting the enzyme 5--reductase

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One of the most important routes connecting the gut and the brain, the vagus nerve, has been postulated to play a role in caudo-rostral spread of PD pathology, with truncal vagotomy appearing to protect against development of PD in both some epidemiological [9, 10] and in vivo [11] studies