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Reduced acinar cell replacement is likely due to decreased cell proliferation rather than cell death as we measured a reduction in Ccnd1 , while markers of cell death [activated caspase3 (CASP3 + ) cells in Fig EV3G or Bax, Pmaip1 (NOXA) and Bbc3 (PUMA) in Fig EV3H)] were either not observed or remained unchanged

Nov 3 2022;27(21)doi:10.3390/molecules27217524 Guo S, Zhou Y, Xie X

The development of atherosclerotic or fibrous plaques within the vascular endothelial cells (ECs) leads to wall stiffening, lumen narrowing, and reduced elasticity, ultimately causing ischemic changes in the corresponding organs

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10.1016/s0006-2952(01)00775-4 71 GautamS.GautamA.ChhetriS.BhattaraiU