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While this broad pattern remains consistent, the distribution of gut bacteria varies both over time and along the digestive tract, with significant differences in diversity and bacterial counts as moving from the esophagus down to the colon and distal gut as depicted in Fig

[Google Scholar] [PubMed] Chattopadhyay A, Navab M, Hough G, Gao F, Meriwether D et al

Importantly, the enzymatic activity of TETs is regulated by 2-oxoglutarate (2OG) as a cofactor and suppressed by metabolites such as 2-hydroxyglutarate (2HG) as a competitor of 2OG