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Although the potential of AFPs has been recognized, the precise mechanisms underlying the antifungal activity of AFPs remain incompletely understood

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However, response variability was noted, with better outcomes in individuals with preserved pituitary function and less severe GHD

Specifically, intracellular zinc exerted an inhibitory effect on Nox2, as demonstrated by increased expression, activation, and activity of Nox2 under zinc deficiency, which was greatly attenuated by zinc enrichment (216)

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