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The April 2026 FDA reclassification has made legitimate access through licensed clinicians and compliant compounding pharmacies more straightforward than it has been in years

It is administered via subcutaneous injection, though oral formulations are also being studied

Gastrointestinal effects are the most frequently reported side effects and include: Nausea (1224% of patients): Often most pronounced during treatment initiation and dose escalation, typically improving over time Diarrhea (1323% of patients): May be transient or persistent, requiring dietary modifications Vomiting (611% of patients): Can lead to dehydration if severe or prolonged Constipation (617% of patients): May require increased fiber intake and hydration Abdominal pain or discomfort (610% of patients): Usually mild to moderate in severity Decreased appetite : Therapeutic effect but may be excessive in some individuals These gastrointestinal symptoms generally diminish over several weeks as the body adjusts to the medication

Injection treatments may be recommended when adequate pain relief is not obtained with oral medication

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