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Accumulation of lactate further supports metabolic flexibility and promotes an immunosuppressive microenvironment

Indeed, DMR analysis detected substantial numbers of differentially methylated regions, many of which were unique for specific media adaptations (Figure 3b)

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FIGURE 1 2.1 Iron metabolism imbalance Iron, an essential trace element, primarily participates in metabolic processes in the forms of Fe 2+ and Fe 3+ (Lee and Roh, 2025)

doi: 10.1172/JCI116842