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The follow-up 2023 systematic review by the same team covered 33 studies and 1,180 participants across 23 different growth factor preparations and concluded that topical growth factor application is effective for facial skin rejuvenation, particularly when delivery is enhanced [6]

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Wild yam extract (vegan phytomucin) In a review from 2023, the authors noted that a compound in wild yams called gracillin may help reduce skin inflammation and, in a mouse study, significantly improved the skin barrier and hydration status of subjects with atopic dermatitis.10 Wild yams also appear to have antimicrobial capabilities, which has led to their use in traditional medicine as a treatment for skin infections, among other things (e.g., cough, menstrual pain, swelling, stomach upset).11 GHK-Cu One of the many potential benefits of topical GHK-Cu is increased skin hydration