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Similarly, animals with deficiencies in indirect scavengers of ROS, such as sulfiredoxin and metallothionein, are highly susceptible to alcohol-induced hepatic injury 27,31

While vitamins exhibit potential in the biological mechanisms and treatment strategies for LLD (Figure 1), concerns regarding species differences, dose-dependent effects, and potential toxicity risks must be addressed

Oxid Med Cell Longev 2020:1452696 Rodriguez-Colman MJ, Dansen TB, Burgering BM (2024) FOXO transcription factors as mediators of stress adaptation

Abstract Context: Autophagy plays a pivotal role in the pathogenesis of DKD, and the mechanistic target of rapamycin (mTOR) pathway, which regulates nutrient sensing and oxidative stress responses, is a key regulator of autophagy

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