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OS stimulates several pro-inflammatory factors and mediators, such as IL-1, IL-6, IL-8, IL-17, IL-24, MCP-1, and TNF-, resulting in an inflammatory cascade (7781)

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Furthermore, in the same study, expression of poly (GR) 80 in neurons increased ROS levels, inducing oxidative stress and dysregulating redox conditions in C9orf72 iPSCs (Lopez-Gonzalez et al., 2016)