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Involving a diverse group of participants aged 65 to 79 with or at risk for age-related diseases, the study utilizes a randomized, double-blind, placebo-controlled design to rigorously evaluate metformins geroprotective effects ( 5.1.3 Caloric restriction mimetics CR - as mentioned previously in this review, has long been associated with enhanced longevity and delayed aging across various organisms, primates and mice included (Xie et al., 2022)

Finally, we outline translational prospects, arguing that targeting this pathway will require precision medicine strategies, including composite biomarkers and rational combination therapies

MTs are cysteine-rich proteins that regulate Zn and copper homeostasis, are involved in heavy metal detoxification (such as cadmium and mercury), alleviate oxidative/nitrosative stress, and participate in immune responses [331]

Before each injection, remove the vial from the refrigerator and allow it to warm to room temperature for 15-20 minutes