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Interestingly, certain muscle groups, notably the rectus abdominis, psoas major, and paraspinal muscles , appeared to display more pronounced changes, which were typified by either an augmentation in muscle density and size or a diminution in fat content

however, these same proprieties can severely hinder the efficiency of the interactions with the target cells once NPs reach the desired tissues, by reducing the tissue penetration because of the higher hydrodynamic diameter, and looser associations with cell membrane because of the repulsive electrostatic charges

Free GSH neutralizes ROS via a REDOX reaction in which glutathione peroxidase oxidizes free GSH into GSSG [11], thereby producing a stable oxygen species and water as a byproduct

Induced genomic instability is manifested as the expression of the following delayed effects: delayed reproductive death or lethal mutation, chromosomal instability, and mutagenesis

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