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Evolutionally, mTORC2-AKT-GSK3 axis was identified as a critical signaling hub to promote the longevity of CD4+ T cells by preventing LCMV-induced lipid peroxidation [257]

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Studies have shown that C/EBP is essential for TanIIA-induced cell differentiation, indicated by the upregulation of CHOP, which controls the expression of key molecules in MDSCs