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More interestingly, they also showed that many variations around this model exist depending on the initial conditions, revealing the complexity of OR regulation now translated to the concept of biased agonism

Author contributions All authors listed have made a substantial, direct, and intellectual contribution to the work, and approved it for publication

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If youre hungover right now, heres what to do in the next 30 minutes: drink something with electrolytes (not just water), take ibuprofen with a full glass of fluid, eat a banana or plain toast if your stomach allows, and get back horizontal in a dark room