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Collectively, our work unveils a novel mechanism by which macrophages handle iron overload in MI hearts and identifies macrophage-derived EVs as a promising iron chelation therapy for the treatment of MI-induced iron overload and cardiac injury

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Treatment duration can vary based on each individuals goals, but many patients undergo treatments lasting several weeks or months

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IGF-1 derivatives, including IGF1-LR3, stimulate cell division and proliferation in various tissues, but they do not promote cell enlargement