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Water is the solvent of life, but it's also a medium for chemical destruction

Towbin, H

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In the early phase of HIRI, DAMPs activate resident immune cells in the liver, particularly Kupffer cells and LSECs, which subsequently induce the production of various inflammatory mediators such as chemokines (CXCL1, CXCL2), cytokines (TNF-, IL-1) and ROS (64)