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Deficiency can result in low bone density particularly of the hip

AdoCbl, MeCbl, CNCbl, and OHCbl, all of which are cob(III)alamins, prefer to adopt a configuration where the DMB ( 5,6-dimethylbenzimidazole, DMB ) nitrogen base is coordinated to the cobalt in the lower axial position (referred to as base-on configuration)

OXPHOS strengthens apoptosis resistance and sustains Th17 persistence by preventing the degradation of apoptosis-regulating factors through mitochondrial autophagy [111]