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For example, in the reaction between thioredoxin reductase (TrxR) and thioredoxin, Se functions as a nucleophile by attacking the redox-active disulfide bond within Trx [63]

Liu, J., Shue, E., Ewalt, K

The Influenza Virus H5N1 Infection Can Induce ROS Production for Viral Replication and Host Cell Death in A549 Cells Modulated by Human Cu/Zn Superoxide Dismutase (SOD1) Overexpression