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Many small randomized trials and observational studies have shown increases in NK cell cytotoxicity, improvements in vaccine response, decreases in infection rates (via antiviral or stimulatory therapy), declines in chemotherapy-associated lymphopenia, and improved patient-reported outcomes (fatigue, QoL) with concomitant use of specific supplements (e.g., mushroom extracts/beta-glucans/ginseng)

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Although these factors have been explored, the data available are still inconclusive (299)

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