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Structural changes such as cardiomyopathy, cardiac hypertrophy, interstitial cardiac fibrosis, endothelial dysfunction, and contractile protein failure can result from elevated oxidative stress in cardiac tissue (Emran et al

FokunangCNHitchcockJSpenceFTembe- FokunangEABurkhardtJLevyLet alAn overview of mitochondrial toxicity of nucleoside reverse transcriptase inhibitors associated with HIV therapy

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Acknowledgements The authors thank the reviewers for very constructive comments that have helped to improve both the accuracy and quality of this article

The midpoint potential of the NAD + /NADH redox pair is 0.32 volts, which makes NADH a moderately strong reducing agent