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(New York, NY: Springer), 107114

doi: 10.3389/fmed.2025.1549658 Received 21 December 2024 Accepted 11 March 2025 Published 26 March 2025 Volume 12 - 2025 Edited by Matteo Becatti, University of Firenze, Italy Reviewed by Laura Vitiello, IRCCS San Raffaele Roma, Italy Francesca Nencini, University of Florence, Italy Updates Copyright 2025 Mao, Liu, Fan, Zhang, Liu and Xiao

This phenomenon is often explained by the Glutathione Depletion-Methylation Cycle Block (GD-MCB) hypothesis , originally proposed to explain how Long COVID can trigger ME/CFS

Zinc preferentially binds to Asp121 at the C terminus and His50 at the N terminus to promote fibrillation

Taken together, our findings demonstrate that neuronal differentiation is accompanied by robust mitochondrial biogenesis and an increase in respiratory capacity