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Chen, C.-Y., Jang, J.-H., Li, M.-H

PMID 28628841

Mitochondrial dysfunction: NRF2 also orchestrates mitochondrial proteins such as superoxide mutase 1 (SOD1), which scavenges mitochondrial ROS and RNS to protect the mitochondrial respiratory chain from oxidative insults (Gumeni et al., 2021) and protein deglycase DJ-1 (PARK7), which maintains mitochondrial complex I activity and the mitochondrial membrane potential, two critical indicators for mitochondrial health (Hayashi et al., 2009

Concentration used in clinical trials: Most positive trials used 80-100 mM (millimolar) solutions

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